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Unlike other carotenoids, fucoxanthin has a unique structure, in which an unusual allenic bond, 9 conjugated double bounds, a 5,6-monoepoxide, and some oxygenic functional groups including hydroxyl, epoxy, carbonyl, and carboxyl moieties are present [55, 56]

Third, exploring synergistic intervention strategies targeting gut microbiota (e.g., probiotic combinations) and ferroptosis (e.g., GPX4 activators) to evaluate their synergistic effects on OA cartilage protection