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This nuanced understanding of FLS phenotypes improves our knowledge on their role in the pathophysiology of OA and may serve as a basis for targeted therapeutic strategies

In addition, maintenance is reduced to almost zero

Without clear diagnostic criteria, clinical trials comparing glutathione to placebo in this population have not been conducted

This mechanism has only been observed in vivo studies and not in vitro studies, highlighting the essential role of the gut-liver axis in regulating ferroptosis [220]