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Cognitive benefits are primarily documented in deficient individuals

2.2 Insulin-like growth factor 2(IGF-2) IGF-2 is a growth factor similar to insulin, primarily active during embryonic development, and involved in cell proliferation and repair in certain adult tissues

At present, there are more than 100 chemical constituents isolated from Rhizoma coptidis, including alkaloids, lignans, flavonoids, and acidic components

Eur J Heart Fail 22:14951503 Seferovi PM, Fragasso G, Petrie M, Mullens W, Ferrari R, Thum T, Bauersachs J, Anker SD, Ray R, avuolu Y, Polovina M, Metra M, Ambrosio G, Prasad K, Seferovi J, Jhund PS, Dattilo G, elutkiene J, Piepoli M, Moura B, Chioncel O, Ben Gal T, Heymans S, Jaarsma T, Hill L, Lopatin Y, Lyon AR, Ponikowski P, Lainak M, Jankowska E, Mueller C, Cosentino F, Lund LH, Filippatos GS, Ruschitzka F, Coats AJS, Rosano GMC (2020) Heart Failure Association of the European Society of Cardiology update on sodium-glucose co-transporter 2 inhibitors in heart failure