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493 Lipid peroxides and their reactive aldehyde derivatives are the key factors in cardiometabolic disorders in obesity, with GPX4 playing a crucial role

Metformin-induced AMPK activation significantly improved renal autophagy, inhibited EMT of renal TECs, reduced tubulointerstitial fibrosis and delayed the onset of DKD (144)

However, conflicting findings exist: a transcriptomic study using the endometrial receptivity array (ERA) test found no difference in receptivity gene signatures during the implantation window between endometriosis patients and controls, and a sibling oocyte study showed no difference in implantation rates in severe endometriosis patients undergoing IVF, suggesting context-dependent effects