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4.3 Multifaceted roles of GPXs in plant biological processes The direct association of GPX2, GPX3, GPX4, GPX5, GPX7, and GPX8 with glutathione metabolic processes ( Figure 5 ) suggests that the proteins can use glutathione as an electron donor in reducing H 2 O 2 or organic and lipid hydroperoxides to maintain plant cell redox homeostasis ( Supplementary Table S2 ) (Yang et al., 2005)