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What can change the answer for an individual Your starting weight and health history Appetite and cravings (how much they drive overeating) Medication tolerance and contraindications Nutrition consistency, sleep, stress, and activity level Follow-up cadence and coaching support Bottom line: For which helps lose weight better, semaglutide generally has the stronger evidence base, while lipotropic injections are best framed as supportive, especially when chosen thoughtfully and used inside a clinician-guided plan

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At 52 weeks, the group continuing tirzepatide experienced an additional 5.5% weight reduction, while the group who switched to the placebo regained 14% of their body weight

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