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In 2007, the WHO declared that prolonged use of statins may induce the development of ALS-like syndrome and may increase ALS risk (Edwards et al., 2007), and this was the first report to suggest the potential link between statin use and ALS risk

These extremely rare side effects include: Reactive thrombocytosis during the first week of use in megaloblastic anaemia Hypersensitivity reactions including: rash, itching, exanthema, antibodies to HYDR0XOCOBALAMIN-transcobalamin II Anaphylaxis Hypokalaemia Headache, paraesthesia, tremor Irregular heartbeat (arrhythmias secondary to hypokalaemia) Nausea Vomiting Diarrhoea Fever, chills, hot flushes, dizziness, malaise, pain and / or swelling at the injection site Acne Abnormal colouration of the urine (chromaturia) What should you not do after a B12 shot

Its side effect profile is milder than both alternatives

Looking ahead, to better navigate and consolidate the complex landscape of DHT applications in rare disease research, we propose an integrated framework (Fig