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[DOI] [PMC free article] [PubMed] [Google Scholar] 107.The Glucagon-like peptide-1 receptor agonist, exendin-4, ameliorated gastrointestinal dysfunction in the Wistar Kyoto rat model of Irritable Bowel Syndrome

Structurally, retatrutide is a 39-amino acid single-chain peptide with a C20 fatty diacid attachment

In the early 1900s, with the advent of new medical therapies and disease perspectives, novel strategies were employed to promote weight loss including thyroid hormone supplementation, and later, amphetamines [1]

While complete Phase 3 data is pending, the trial design incorporates the escalation framework validated in Phase 2 starting at lower doses and escalating over defined intervals to target maintenance doses