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In addition, GLP-1RAs are valuable in the treatment and prevention of diseases of the nervous and cardiovascular system, endocrine disorders, or metabolic diseases due to their neuroprotective, cardiovascular protective, and metabolic regulatory effects

They wrote: "The VETPROOF, reported here, suggests that enalapril treatment provides a modest benefit in delaying onset of CHF, whereas the first and larger of these studies, the SVEP trial, does not." The VETPROOF authors further acknowledged the importance of SVEP's 229 cavaliers versus their multi-breed enrollment with only ten cavaliers