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FDA Approval Status: A Key Distinction It is important to understand the official standing of these treatments: Oral Glutathione Tablets are FDA approved for treating serious illnesses like liver diseases and for patients undergoing chemotherapy Intravenous (IV) Glutathione does not have FDA approval for the purpose of skin lightening Furthermore, the specific long-term side effects that may occur from using IV Glutathione for cosmetic purposes are currently unknown Side Effects of Oral Tablets (Lower Risk) Oral Glutathione generally has few side effects