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Limitations include relatively short treatment periods (6 weeks per arm), potential carryover effects despite washout, modest sample size limiting power for subgroup analyses and exclusion of newer agents (e.g., tapentadol) and long-term safety outcomes, which may restrict applicability to broader clinical practice

Association of periodontitis, missing teeth, and oral hygiene behaviors with the incidence of hypertension in middle-aged and older adults in Korea: A 10-year follow-up study