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6.2 Irisin and the endocrinology of exercise Irisin, a peptide cleaved from the transmembrane protein FNDC5 and released from skeletal muscle during exercise, represents a parallel and more controversial example of muscle-derived endocrine signaling

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10.1038/s41598-025-89408-z 32 HeerspinkH.SattarN.PavoI.HauptA.DuffinK