glp-1 drugs retatrutide vs Tirzepatide Compared Next-Gen GLP-1 after Ozempic: Retatrutide

[40] reported that liraglutide 3.0 mg over 24 weeks achieved modest BW loss of about 2.5% but substantial reduction in FBM, particularly in the android region

The peptide incorporates two key modifications from native GIP: an aminoisobutyric acid (Aib) substitution at position 2 for DPP-4 resistance and a C-20 eicosanedioic fatty diacid moiety linked at Lys20 via a Glu-2xOEG spacer for albumin binding and half-life extension

10.1016/j.cell.2022.11.001 132 MadeoC.-G.KroemerKroemerG

It has been proposed that CPT1A contributes to cell survival, not only by increasing FAO 29 but also by stimulating histone acetylase activity in the nucleus 30