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While effective, this treatment is costly, not widely available, and can place significant stress on the liver and kidneys

Naturally occurring peptides play pivotal roles in a wide range of physiological processes, including but not limited to: Cellular signaling Cellular motility Hormonal regulation Immune regulation At the same time, peptides are selective in their affinity, which also helps minimize unwanted interactions

Conjugation of the nonsignaling COOH-terminus of this modified PTHrP to a linear peptide of 20 D-glutamic acid residues (D-Glu 20 ) allowed for retention of PTHrP signaling activity following its adsorption to exposed hydroxyapatite

It is highly expressed in growth cones during axonal elongation, neural regeneration, and synaptic remodeling