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Appendicitis can be caused by various factors, including: Blockage of the appendix by hardened stool, a foreign body, or cancer Infection in the body that causes the appendix to swell Certain conditions such as appendix stones, lymphoid hyperplasia, colitis, tumors, parasites, or cystic fibrosis Diagnosing appendicitis can be challenging, as the symptoms may resemble those of other illnesses

R.MahajanA.KurilshikovA.Vich VilaA.VsaU.et al (2019)

Similarly, other large trials have shown neutral results for cardiovascular endpoints