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Bergenstal RM, Forti A, Chiasson JL, Woloschak M, Boldrin M, Balena R

Support for your GLP-1 journey While digestive side effects can be uncomfortable at-first, they are usually temporary and manageable

Mounjaro/Zepbound (tirzepatide), approved dual GLP-1/GIP agonist for type 2 diabetes and obesity Recent Highlights: In April 2026, the FDA approved orforglipron (Foundayo), making it one of the first oral GLP-1 pills that can be taken any time of day and that has no food or water restrictions

By the 1980s, the amino acid and gene sequences of proglucagon (Figure 1) were unraveled