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Another possibility, said Miras, was that a genetically predetermined set point for body weight had a broader range for some people than others, meaning their body did not resist efforts to deviate from this weight as strongly as for other people

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Efficacy and safety of once-weekly semaglutide versus once-daily insulin glargine as add-on to metformin (with or without sulfonylureas) in insulin-naive patients with type 2 diabetes (SUSTAIN 4): a randomised, open-label, parallel-group, multicentre, multinational, phase 3a trial

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