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Overall, a moderate intake is recommended, and to be attentive to how the body reacts
The co-primary endpoints, percent change in body weight from baseline and proportion of patients achieving 5% weight loss, were identical to those of SURMOUNT-1, as were the two estimands: the TRE (which included all patients who were randomized) and the efficacy estimand (which included randomized patients who remained on the study treatment for the entire efficacy assessment duration of the trial)
It is the most pharmacologically ambitious incretin molecule in clinical development and produced the largest mean weight reductions ever reported for any obesity drug, exceeding 24% at the highest dose after 48 weeks
Protein expression and purification Expression and purification of TRF1 TRFH domains was carried out as described previously with some modifications 15,31
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