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This pharmacological distinction is important for researchers designing experiments that depend on sustained versus transient receptor activation

Nevertheless, oxyntomodulin can be cleaved by DPP-4 in vitro (36, 56), and in animal studies, the anorectic effects of exogenous oxyntomodulin are increased after DPP-4 inhibition (56), while DPP-4-resistant oxyntomodulin analogs have been associated with improved glucose tolerance, reduced food intake, greater energy expenditure, and weight loss (57, 58)

Yes, this can happen under certain conditions

This does not affect reconstitution, but it means the mechanism of action differs