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The intrinsically disordered interdomain region between the helicase and nuclease domains of an archaeal Hef protein from Thermococcus kodakarensis was shown to be involved in interactions with multiple proteins including PCNA1 and a RecJ-like protein, suggesting that Hef acts as a scaffold and uses this IDR for sequential interaction with several proteins to control the repair pathway at the stalled fork (Ishino et al., 2014)

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How does Delta Sleep-Inducing Peptide Work

In addition, in patients with organ failure, the syndecan-1 and VE-cadherin concentrations increase, whereas that of sphingosine 1-phosphate (S1P) decreases