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At the GIPR, tirzepatide triggers Gs-mediated cAMP production in adipocytes and pancreatic beta cells, enhancing insulin secretion, improving fat storage efficiency in subcutaneous depots, and increasing lipid buffering capacity
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To orient readers to the clinical scope of the review, Figure 1 summarizes the fertility-centered decision landscape across the metabolicreproductivepregnancy continuum (Panel A)
Starting at the full target dose would produce maximum GI effects immediately, reducing tolerability and potentially causing research subjects to discontinue
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