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To isolate the cumulus cells, they were initially treated with 40 IU/mL hyaluronidase (SynVitro Hyadase, Origo, Knardrupvej, Denmark) for 3 min, followed by thorough washing with phosphate-buffered saline (PBS)

Daily GnRH antagonist injections (Cetrotide 0.25 mg, Pierre Fabre Medicament Production, Aquitaine Pharm International, Idron, France) were started when the leading follicle reached 1214 mm in diameter and continued until the final oocyte maturation

Niacinamide at the doses used in compounded tirzepatide is considered safe long-term, as it is a naturally occurring vitamin

1 Introduction Hypothyroidism is a prevalent endocrine disorder defined by inadequate synthesis or secretion of thyroid hormones, primarily thyroxine (T 4) and triiodothyronine (T 3) (McDermott, 2020)