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380,381 Signaling pathways associated with inflammatory cytokines TNF- signaling pathway The TNF- signaling pathway, a critical part of the initiation phase, promotes liver repair and regeneration through the synergy of different liver cells

Many agents also show favorable effects on body weight and some cardiovascular risk factors, which is why clinicians increasingly consider them for broader cardiometabolic indications

Participants with the highest body mass index (BMI) values (40 or above) were most likely to access semaglutide, which is not surprising given that this group has the highest risk for developing further metabolic diseasebut Podolsky says it reflects a trend that physicians may be restricting GLP-1 drugs to patients with the highest weight, and solely recommending lifestyle interventions to patients with BMI values of 35 or less