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Mice that lack an organised synovial lining layer due to the deficiency of cadherin-11 are indeed resistant to the development of arthritis, demonstrating a causal role of fibroblasts in the disease ( + THY1 + cells are mainly mediators of inflammation, the destruction of joint tissues is mostly mediated by FAP + THY1 - fibroblasts ( The driving role of fibroblasts in cancer is also well studied

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Systematic reviewGLP-1 class evidence2025 Efficacy of GLP-1 Receptor Agonists on Weight Loss, BMI, and Waist Circumference A broad meta-analysis anchor for GLP-1 weight-loss effect and class-level comparisons

the differential response at dynamic PDU in mildmoderate and severe vasculogenic ED highlighted by the current study might rely on an insufficient intracavernous l-ARG delivery, upon oral administration of l-ARG at the tested doses, unable to counteract a severe vascular impairment, therefore suggesting the potential requirement of higher l-ARG supplementation regimens in these patients, although in some cases of severe vasculogenic ED an irreversible vascular damage cannot be ruled out