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Clinical guidance from NHS Lothian suggests that if you are on oral progesterone and starting a GLP-1 medication, it may be logical to increase the dose from 100 mg daily to 200 mg daily for the first 4 weeks of GLP-1 treatment, after which the gastroparesis risk typically diminishes at a stable dose

This delayed gastric emptying is one reason these medications help control appetite, but it also means that food consumed before a workout may sit in your stomach longer than you expect

Obesity (Silver Spring) 28 , 529536 (2020)

A Phase 1a, blinded, placebo-controlled, randomized, single- and multiple-ascending-dose study was done to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of single and multiple doses of orforglipron