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History [edit] Descriptions of deficiency effects [edit] Between 1849 and 1887, Thomas Addison described a case of pernicious anemia, William Osler and William Gardner first described a case of neuropathy, Hayem described large red cells in the peripheral blood in this condition, which he called "giant blood corpuscles" (now called macrocytes), Paul Ehrlich identified megaloblasts in the bone marrow, and Ludwig Lichtheim described a case of myelopathy

The powder should dissolve within a few minutes

These are pathway-level insights

Moreover, while microbial genes associated with secondary bile acid biosynthesis showed differential abundance at the early stage, pathways related to LPS biosynthesis and lipid metabolism were abundant at the advanced stage (Wu et al., 2020a)