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Mel has been shown to regulate multiple molecular pathways, including inflammation, oxidative stress, apoptosis, and autophagy, under various pathophysiological conditions.32 Cas-3 is the most critical executioner in the caspase family and represents the final common substrate of both intrinsic and extrinsic apoptotic pathways.32 Once activated, Cas-3 cleaves this substrate, thereby reflecting the progression of apoptosis.33 In the present study, CARB treatment appeared to initiate this process in ovarian tissue, as evidenced by intense Cas-3 immunoreactivity

Modulation of gene expression in pineal and peripheral tissues, including genes tied to circadian rhythm regulation, melatonin synthesis, stress response, and cell-cycle control

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(PubMed) Ying Z, Kampfrath T, Sun Q, Parthasarathy S, Rajagopalan S