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When endogenous catecholamines (adrenaline and noradrenaline) bind to these receptors, the Gs-protein is de-coupled, leading to: Activation of adenylyl cyclase Conversion of ATP to cyclic AMP (cAMP) Activation of downstream intracellular pathways There are three -adrenoreceptor subtypes: 1, 2, and 3

The same degree of telogen effluvium that would be unnoticeable in a 30-year-old can be visually significant in a 65-year-old who already has thinner baseline hair

These all correlate with peak drug levels