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Abbreviations GCGR: Glucagon receptor GIP: Glucose-dependent insulinotropic polypeptide GIPR: Glucose-dependent insulinotropic polypeptide receptor GLP-1: Glucagon-like peptide-1 GLP-1R: Glucagon-like peptide-1 receptor NAFLD: Non-alcoholic fatty liver disease NASH: Non-alcoholic steatohepatitis STEP: Semaglutide Treatment Effect in People with Obesity References Bray GA, Kim KK, Wilding JPH (2017) Obesity: a chronic relapsing progressive disease process

This paper describes the ability of an oral peptide delivery formulation, Axcess, to enhance uptake of GLP-1 receptor agonists via the intestine, resulting in changes in insulin and glucose blood levels indicative of biopotencies of 9% for exendin-4 and 14.8% for semaglutide in preclinical models