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The molecular mechanisms primarily involve excessive activation of the unfolded protein response triggered by endoplasmic reticulum stress in granulosa cells [350], leading to caspase cascade-dependent apoptosis, as well as DNA strand breaks and membrane lipid peroxidation induced by mitochondrial electron transport chain leakage in spermatozoa [351, 352]

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Another trial found glutathione to be supportive of immunity by its ability to modulate NK and T-cells responsible as front-line defenders, protecting against microbial infections