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doi: 10.1186/s12951-022-01661-w 376

TNF- blockers, nuclear factor kB inhibitors, antiangiogenic agents, statins, antioxidants, immune-modulators, flavonoids, histone deacetylase inhibitors, matrix metalloproteinase inhibitors, metformin, novel modulators of sex steroids expression, and apoptotic agents were all effective in vitro and/or in animal models

Understanding nutrition, depression and mental illnesses

It's frequently referenced alongside MOTS-c and NAD+ in research contexts, given the complementary nature of their respective pathway interactions - particularly how NNMT inhibition influences NAD+ availability in metabolic signalling studies