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Keeping weight off: mindfulness-Based Stress Reduction alters amygdala functional connectivity during weight loss maintenance in a randomized control trial

Both medications carry the same boxed warnings

It is possible that for some people, a lower dose may produce fewer side effects, but it will likely be less effective for most people

When administered therapeutically, GLP-1 receptor agonists work through several mechanisms: Enhancing insulin secretion from pancreatic beta cells in a glucose-dependent manner [1] [4] Suppressing glucagon release from alpha cells, reducing hepatic glucose output Slowing gastric emptying , which helps moderate post-meal blood glucose rises Promoting satiety through central nervous system pathways, potentially supporting weight reduction Investigational transdermal GLP-1 delivery systems typically utilise specialised technologies such as microneedles or active delivery methods rather than conventional patches, as GLP-1 molecules are large peptides that do not easily penetrate the skin barrier