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This suggests that the chronic fasting state induced by kin-19 RNAi under ad libitum fed conditions is, at least in part, dependent on NHR-49 activity

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The enduring effectiveness, advantageous safety profile, and supplementary metabolic advantages place these medicines as primary pharmacological choices for obesity management, especially in individuals with metabolic disorders

The article says these medications bind GLP-1 receptors on pancreatic beta cells, stimulating insulin secretion when blood glucose rises, while simultaneously signalling satiety centres in the hypothalamus to reduce appetite and slow gastric emptying