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Acute high dose toxicity of TCs is characterized by diarrhea, vomiting, leukocytosis, haemorrhage, and circulatory shock and death, whereas chronic low dose toxicity is characterized by anorexia, reduced weight gain, neuroendocrine and immunologic changes [91, 94]

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This often results in poor texture of the skin and becomes a reason behind the appearance of dryness and roughness, which leads to premature aging

Finally, the absence of validated biomarkers for predicting treatment response or monitoring efficacy further complicates both clinical research and practical application, limiting the ability to personalize therapy or objectively assess outcomes