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Patients with higher baseline body mass index (BMI) or more severe insulin resistance may experience different response patterns compared to those with milder metabolic dysfunction

Recent studies show that these medications might also significantly help reduce symptoms of obstructive sleep apnea (OSA), a prevalent and frequently overlooked condition strongly associated with obesity

The results showed that tesofensine, particularly at a dose of 0.5 mg, led to a significant improvement in the total UPDRS score (-4.7 points) and a reduction in off time (-7.1%)

Some women find that stepping back to a lower dose and titrating up more slowly resolves the issue without sacrificing weight loss efficacy