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of 10% in the difference 46,47,48 , 23 participants would provide 80% power to detect this difference at a 5% significance level

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the clinical significance in most individuals is uncertain but should be monitored [1] [8] Gallbladder-related events including gallstones (cholelithiasis), which have been associated with GLP-1 receptor agonists and with rapid weight loss more generally [8] [9] Many participants also describe a general feeling of fullness after eating very small amounts of food, which is a direct consequence of delayed gastric emptying