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Post-hoc test showed that the comparison between Groups 1 and 2 was significant, while the comparison between all other groups was statistically non-significant (Table 1, D)

Oxidative stress has been implicated in the pathophysiology of cancer: in fact, high levels of ROS generated by ongoing aerobic glycolysis followed by pyruvate oxidation in mitochondria (the Warburg effect), increase receptor and oncogene activity, and the stimulation of growth factor-dependent pathways or oxidizing enzymes induce genetic instability 3,4