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According to international guidelines, GLP-1RAs are recommended for patients with type 2 diabetes who have established atherosclerotic cardiovascular disease or are considered at high cardiovascular risk
It has been shown that HSYA was able to significantly protect the liver from oxidative stress by increasing the activities of antioxidant enzymes, upregulating the expression of PPAR- and MMP-2, and downregulating the expression of TGF-1 and tissue inhibitor of metalloproteinases-1 (TIMP-1), and reducing -SMA level, which indicating that PPAR-TGF-1 would be a signal pathways for HSYA to reduce liver fibrosis induced by oxidative stress (Wang et al., 2013)
Miller RP, Roberts RJ, Fischer LJ
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