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The pivotal trial supporting its 2010 FDA approval enrolled 816 HIV-infected adults with clinically defined lipodystrophy, and Phase 3 data documented visceral fat reductions of roughly 15-18% over 26 weeks of treatment a result robust enough to clear FDA review for a defined medical indication

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It remains reserved for severe cases unresponsive to medical management

If you are symptomatic with a lot of GI issues, particularly constipation, you are at risk.