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The pivotal role of the gut microbiota is underscored by evidence demonstrating that the protective effects of a steamed broccoli sprout diet against colitis are entirely dependent on its presence, as it generates bioactive sulforaphane in the colon even when the plants own myrosinase is inactivated (51)

B12 supplement dosing For long term B12 supplementation, data suggests that it is a good idea to stay beneath a daily dose 0.4 mg, or 400 mcg, as higher doses may increase cancer risk

[DOI] [PubMed] [Google Scholar] Jin Y., Chen J., Xie W., Zhang J., Yan J., Chen C., Lin J., Cai Z., Lin Z

131 Nevertheless, most of the evidence gathered to date was derived from smaller mechanistic studies, and the few large randomized controlled trials have not shown a significant mortality benefit of using these agents