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BMI and Health Condition Requirements Eligibility for GLP-1 medications such as Ozempic often includes one of the following: A BMI of 30 or higher, which falls within the medical definition of obesity A BMI of 27 or higher with at least one weight-related health condition Weight-related conditions that may support eligibility include: High blood pressure (hypertension): Excess weight increases strain on your heart and blood vessels, raising long-term cardiovascular risk

The drug has mild side effects, such as hypertrichosis, or excessive hair growth, and hyperglycemia

Other mechanisms that regulate the intracellular iron abundance, such as the exportation of iron via various multivesicular bodies and exosomes carrying ferroportin or prominin2-mediated ferritin, can also affect the cellular sensitivity to ferroptosis, as they deplete the cellular iron and accelerate the lipid peroxidation (53) ( Figure 1 )