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Autophagy 9 , 21262139 (2013)

The World Anti-Doping Agency has banned these compounds, noting they lack approval from any health regulatory authority and are intended only as research tools

This approach addresses challenges associated with traditional peptides, including limited enzymatic stability in the gastrointestinal tract and serum, inadequate absorption, rapid excretion through hepatic and renal pathways, compromised targeting capabilities arising from the intrinsic rotational flexibility of amino acids, and the potential for inducing antigenicity and unpredictable immune responses