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The APCs are organized such that each group is homogeneous both clinically and in terms of resource use

Taken together, substratification of AF phenotypes may allow the combination of different mechanism-specific drugs (direct anti-arrhythmic atrial-selective channel-modifying drugs as well as modifiers of remodelling processes, inflammation etc.) and interventional therapies guided by the disease subtypes [130]

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Future FDA action may likewise be specific rather than universal