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Under TNF-induced inflammatory conditions, GLP-1RAs (such as Exendin-4 and GLP-1) suppress the production of MMPs in human coronary artery smooth muscle cells (hCASMCs) by inhibiting AKT-Thr308 phosphorylation

Eye wrinkle improved by 12.1%, smoother skin texture by 9%, improved skin droopiness by 4.8%, skin density improved by 6.2%, freckle and blemish reduced by 12.5%, and melanin level reduced by 3.25% after 4 weeks of use

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