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Our CLP model showed chronic Nrf2/HO-1/GPX4 suppression (day 7) linked to GSH depletion, ferroptosis, and irreversible antioxidant collapse (Xie et al., 2020), supporting Nrf2 activators (e.g., sulforaphane) or GSH precursors (e.g., NAC) as interventions (Yusri et al., 2025)

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Secondary outcomes Secondary outcomes included cardiovascular mortality, all-cause mortality, non-fatal myocardial infarction (MI) and stroke, as well as hospitalisation for heart failure

The Na + /Ca 2+ exchanger (NCX) is a neuronal reciprocal Ca 2+ transporter that promotes neuroprotection