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Accurate stratification must be coupled with a deep understanding of an individuals unique biological landscape, a feat now achievable through multi-omics and novel biomarkers

The evidence in this review found that there is probably no difference between PDE and alpha blockers, however when used in combination they may provide a greater improvement in symptoms (with more side effects)

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compared the effects of cotadutide (a dual GLP-1/GCG receptor agonist), liraglutide, and obeticholic acid in two mouse models of NAFLD [amylin liver NASH (AMLN) diet mice and AMLN diet ob/ob mice] to show that cotadutide outperformed other treatments in improving major histological endpoints, i.e., hepatic steatosis, inflammation, NAS, and fibrosis