Vitamin C (ascorbic acid) is itself a potent water-soluble antioxidant, and just as importantly, it helps regenerate oxidised glutathione back into its active form
In the endoplasmic reticulum, it also acts like a built-in quality-control partner, supporting proper protein folding and helping prevent misfolded proteins from accumulating
in-vitro study found that berberine protected NSC34 cells from H 2 O 2 -induced cytotoxicity by reducing ROS production, restoring glutathione, and superoxide dismutase activity, and activating the production of antioxidant proteins nuclear factor erythroid 2-related factor-2 (Nrf2) and HO-1 ( Studies have found that berberine has an antidepressant effect (Figure 1)
Glutathione, often called the bodys master antioxidant , directly neutralizes free radicals and supports detoxification, liver health, and immune balance