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As a result, labile iron accumulates in renal cells, providing a catalytic basis for lipid peroxidation (Wang W

7 In the phase 2 monotherapy trial these events were generally mild to moderate, most frequent during dose escalation, and tended to diminish with continued treatment

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Mechanistically, the metabolic benefits of Godex depend on enhanced activity of CrAT, which modulates mitochondrial acetyl-CoA metabolism and thereby improves insulin sensitivity and hepatic lipid homeostasis (80), whereas some human studies report only modest reductions in liver enzymes without significant changes in broader metabolic parameters (64)