And yes, one of these new GLP-1s can be a part of the solution

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Small molecule programs remain high risk high reward Pfizers pullback from its own oral GLP-1 programs has highlighted a major scientific challenge: biased agonism can improve GI tolerability but does not eliminate hepatotoxicity risk
Diagnosis relies on B12 levels, methylmalonic acid, homocysteine, and intrinsic-factor antibodies interpreted by a clinician