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SOUL trial: Oral semaglutide 14 mg demonstrated superior reduction in risk of CV events owenhaskins Mar 31, 2025 2 min read e full results from the SOUL cardiovascular outcomes trial, investigating the effects of Rybelsus (semaglutide) tablets 14 mg on reducing the risk of major adverse cardiovascular events (MACE) in adults with type 2 diabetes and ASCVD and/or CKD, achieved its primary endpoint demonstrating a 14% reduction in risk of MACE (2% absolute risk reduction at 3 years) compared to placebo (579 vs 668 events
Of note, the prevalence of HF varied across these trials from 9% to 24%, and HF events were considered a secondary endpoint
Evolution of caspase-mediated cell death and differentiation: twins separated at birth
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